freecolor Certificates Ames Test | Ames Test |
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The Ames Test enables demonstration of a potential mutagenic effect of substances or their impurities, as these generate typical changes in the DNA of bacteria. These are then considered to be mutagenic in the Ames Test (Ames positive). The test serves as a quick assay and is widely used in the chemical and pharmaceutical industries. All materials used in freecolor toner cartridges are tested according to these criteria and contain no substances which affect human genetic material. Test procedure:Bacteria which have point mutations in a gene and are thus no longer capable of synthesizing a particular amino acid (auxotrophy), are spread on a medium (agar) which does not contain this amino acid. Since these bacteria cannot survive without this amino acid, the auxotrophs would die or cease to proliferate on this deficient medium.
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The Ames Test is a bacterial method of
testing substances for mutagenic characteristics (mutagenesis test). This test
was developed in the early 1970s and was named after its inventor, Prof. Bruce
Ames*. The Ames Test is "negative" if no mutagenic changes can be
detected.
